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octreotide (Sandostatin)…

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What is octreotide injection, and how does it work (mechanism of action)?

Octreotide acetate is an injectable medicine that is very similar to the hormone somatostatin, which is naturally produced in the body that has several effects including inhibition of the release of hormones. Octreotide works in a similar fashion as somatostatin, but is degraded more slowly and is a stronger inhibitor of glucagon, growth hormone, and insulin release. Like somatostatin, octreotide also decreases the release of growth stimulating hormones, decreases blood flow to the digestive organs, and inhibits the release of digestive hormones such as serotonin, gastrin, vasoactive intestinal peptide, secretin, motilin, and pancreatic polypeptide. Based on these actions, octreotide acetate is used to treat symptoms of severe diarrhea and flushing caused by cancer.

Octreotide is also used to treat acromegaly. Acromegaly is a rare hormonal disorder that affects adults in which there is an over production of growth hormone that leads to the abnormal growth of the hands, feet, or facial features. Octreotide significantly decreases the levels of growth hormone and IGF-I (somatomedin C) in patients with acromegaly.

Other actions of octreotide include suppression of thyroid stimulating hormone (TSH) release, inhibition of gallbladder contractility, and the secretion of bile.

The FDA approved octreotide acetate in October 1988.

What brand names are available for octreotide injection?

Sandostatin, Sandostatin LAR

Is octreotide injection available as a generic drug?

Yes

Do I need a prescription for octreotide injection?

Yes



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